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Purulent-restorative fever manifested worsening condition of patients, the appearance and progression of pain in the wound, persistent fever, changes in the blood (leukocytes, left shift in leukocyte counts, increased sedimentation rate). The urine protein appears, the number of white blood cells, appear hyaline cylinders. 
An important feature of toxic-restorative fever is its dependence on primary purulent focus: the liquidation of its purulent-restorative fever passes.

The incubation period in sepsis is different - from several hours to several weeks or even months. Based on the clinical course of sepsis, secrete acute, sub acute and chronic sepsis. An unfavorable course of acute sepsis leads to the death of patients in the period from 2 to 15 days, sub acute - from 16 days to 2 months, chronic - from 2 up to 3-4 months. 
For acute sepsis is characterized by high temperature-type constant fever, sometimes with very few remissions. His condition was grave. Skin pale, with an earthy tint in his cheeks a feverish glow. In the last days of life in 25% of injuries observed jaundice in one degree or another. Possible euphoria, insomnia, irritability. 

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