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On the background of demarcation and the gradual exclusion of non-viable tissue in some parts of the islands of granulation wounds appear, usually not before 5-6 days after the injury. Appearance of granulation means the beginning of the transition from the inflammatory phase to the phase of regeneration. Active granulation means an offensive second phase of wound healing process - the phase of regeneration. 
Granulation tissue consists mainly of newly formed capillaries. Around them are concentrated fat cells that secrete biologically active substances, contributing to the formation of capillary networks.

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